AHN 1-055 hydrochloride

CAS No. 202646-03-5

AHN 1-055 hydrochloride( 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride )

Catalog No. M28222 CAS No. 202646-03-5

AHN 1-055 hydrochloride is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 46 Get Quote
10MG 72 Get Quote
25MG 147 Get Quote
50MG 233 Get Quote
100MG 349 Get Quote
200MG 525 Get Quote
500MG 788 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    AHN 1-055 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    AHN 1-055 hydrochloride is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM).
  • Description
    AHN 1-055 hydrochloride is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM). AHN 1-055 hydrochloride may serve as a lead for the development of agents for the treatment of cocaine abuse.(In Vivo):In adult male Sprague Dawley rats, AHN 1-055 hydrochloride (5 mg/kg; i.v.) inhibited the uptaking of brain dopamine with an IC50 of 311.8 ng/ml. The Cmax and T1/2 are 1.48 mg/L and 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Adult male Sprague Dawley rats (250-275 g)Dosage:5?mg/kg (Pharmacokinetic Analysis)Administration:I.v. administration Result:Cmax (1.48 mg/L); T1/2 (7.69 h).
  • Synonyms
    3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    EGFR (wt)|EGFR (L858R)|EGFR (L861Q)|EGFR (L858R/T790M)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    202646-03-5
  • Formula Weight
    379.87
  • Molecular Formula
    C21H24ClF2NO
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (263.25 mM)
  • SMILES
    CN1[C@@H]2C[C@@H](OC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C[C@H]1CC2.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Luwei Han, et al. SH-1028, An Irreversible Third-Generation EGFR TKI, Overcomes T790M-Mediated Resistance in Non-Small Cell Lung Cancer. Front Pharmacol. 2021 Apr 27;12:665253.
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