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Home - Products - GPCR/G Protein - Dopamine Receptor - AHN 1-055 hydrochloride

AHN 1-055 hydrochloride

CAS No. 202646-03-5

AHN 1-055 hydrochloride( 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride )

Catalog No. M28222 CAS No. 202646-03-5

AHN 1-055 hydrochloride is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 46 Get Quote
10MG 72 Get Quote
25MG 147 Get Quote
50MG 233 Get Quote
100MG 349 Get Quote
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Biological Information

  • Product Name
    AHN 1-055 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    AHN 1-055 hydrochloride is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM).
  • Description
    AHN 1-055 hydrochloride is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM). AHN 1-055 hydrochloride may serve as a lead for the development of agents for the treatment of cocaine abuse.(In Vivo):In adult male Sprague Dawley rats, AHN 1-055 hydrochloride (5 mg/kg; i.v.) inhibited the uptaking of brain dopamine with an IC50 of 311.8 ng/ml. The Cmax and T1/2 are 1.48 mg/L and 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Adult male Sprague Dawley rats (250-275 g)Dosage:5?mg/kg (Pharmacokinetic Analysis)Administration:I.v. administration Result:Cmax (1.48 mg/L); T1/2 (7.69 h).
  • Synonyms
    3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    EGFR (wt)|EGFR (L858R)|EGFR (L861Q)|EGFR (L858R/T790M)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    202646-03-5
  • Formula Weight
    379.87
  • Molecular Formula
    C21H24ClF2NO
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (263.25 mM)
  • SMILES
    CN1[C@@H]2C[C@@H](OC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C[C@H]1CC2.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Luwei Han, et al. SH-1028, An Irreversible Third-Generation EGFR TKI, Overcomes T790M-Mediated Resistance in Non-Small Cell Lung Cancer. Front Pharmacol. 2021 Apr 27;12:665253.
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